Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2. 11/09/2015Etoposide is a chemotherapy drug, used to treat lung and ovarian cancer The drug is made using an ingredient from rare Himalayan mayapple plant Scientists have … 23/11/2018Etoposide is a drug that is used in chemotherapy and is classified as a plant alkaloid and a topoisomerase II inhibitor. Plant alkaloids are substances from plants. Etoposide is also referred to as VP-16, Toposar, VePesid or etopophos by doctors.Etoposide concentrate for solution for infusion 20 mg/ml must be diluted immediately prior to use with either 5% glucose or 0.9% sodium chloride solution to give a concentration range from 0.2 to 0.4 mg/ml, usually not more than 0.25 mg/ml for the final concentration.Etoposide is currently synthesized from podophyllotoxin, a natural product first isolated from the Himalayan mayapple plant, Podophyllum hexandrum.Side effects of etoposide (Eposin, Etopophos, Vepesid) Contact your doctor or nurse immediately if any of your side effects get severe or if you have signs of infection, including a temperature above 38C. The side effects may be different if you are having etoposide with other cancer treatments.Podophyllotoxin is a plant product incorporated into a cream medication called podofilox and used for viral skin infections. It is used in topical applications for illnesses such as warts. The cancer drugs Etoposide and Tenisopide are derived from podophyllotoxin. 09/04/2012MeSH Terms. Etoposide/pharmacology* Genes, Plant Genetic Loci Genomic Instability Genotype Inheritance Patterns Oryza/drug effects Oryza/genetics* Oryza/metabolism Penetrance viagra us Plant Cells/drug effects Plant Cells/metabolism Seeds/drug effects Seeds/genetics Self-Fertilization http://canadabuyes.com sildenafil ingrediente activo viagra generico Topoisomerase II Inhibitors/pharmacology 10/07/2012Etoposide is an anticancer agent, which is successfully and extensively used in treatments for various types of cancers in children and adults. However, due to the increases in survival and overall cure rate of cancer patients, interest has arisen on the potential risk of this agent for therapy-related secondary leukemia.