Original Article Immediate hypersensitivity to quinolones: moxifloxacin cross-reactivity I. Gonzlez, T. Lobera, A. Blasco, M D. del Pozo Section of Allergy. Hospital San Milln. San Pedro Logroo. La Rioja. Spain Introduction Immediate hypersensitivity reactions to quinolones are rare, ranging in frequency from 0.4% to 2% [1], andOne group reported a case of allergy to moxifloxacin in which ciprofloxacin and norfloxacin were well tolerated [11]. We previously confirmed cross-reactivity between moxifloxacin, a fourth-generation quinolone, and ciprofloxacin and ofloxacin [4]. It seems that there is no way of predicting cross-reactivity. Different http://canadabuyes.com name brand viagra online pharmacy patterns of cross Immediate hypersensitivity to quinolones: moxifloxacin cross-reactivity. Gonzales, I, et al. J Invest Allergol Clin Immunol 2005; Vol.15(2):146-149 Patient Years Sex Clinic Culprit drug 1 39 female urticaria ciprofloxacin 2 50 female urticaria moxifloxacin 3 29 female urticaria ofloxacin ciprofloxacin 4 42 female urticaria ciprofloxacin 5 63 female anaphylaxis moxifloxacin 6 53 male urticaria Similarly, 3 of 4 levofloxacin-reactive patients tolerated ciprofloxacin. Patients who reacted to moxifloxacin and norfloxacin tolerated ciprofloxacin and levofloxacin. CONCLUSIONS: Our results suggest that skin testing and BAT do not help to identify the culprit drug or predict cross-reactivity. Oral challenge testing is the only way to c = There is little potential for cross-reactivity between penicillin / cephalosporins and carbapenems; however, monitor closely if previous anaphylactic reaction to penicillins or cephalosporins X = Potential for cross-sensitivity Blank = Not cross-sensitiveSimilarly, 3 of 4 levofloxacin-reactive patients tolerated ciprofloxacin. Patients who reacted to moxifloxacin and norfloxacin tolerated ciprofloxacin and levofloxacin. CONCLUSIONS: Our results suggest that skin testing and BAT do not help to identify the culprit drug or predict cross-reactivity. Oral challenge testing is the only way to The mean cross-reactivity of moxifloxacin with the amphetamines assay was the highest we observed at 0.184% . For the remaining fluoroquinolone/assay pairs, the highest concentration sample produced results similar to the blank sample. Notably, ciprofloxacin did not cross-react with any of …INTRODUCTION: Immediate hypersensitivity reactions to quinolones are rare. Moxifloxacin is an quinolone chemically different from other fluoroquinolones. We report 6 patients diagnosed with hypersensitivity to different fluoroquinolones in whom the response to moxifloxacin and cross-reactivity with other quinolones was studied.Human Resources for the University of Oklahoma. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses.ObjectiveTo report 3 cases of immediate hypersensitivity reactions to moxifloxacin in patients who tolerated ciprofloxacin.Case summariesA 71-year-old man, a 44-year-old woman, and a 70-year-old woman with a history of a moxifloxacin reaction developed an immediate hypersensitivity reaction upon oral challenge with moxifloxacin in our Drug The 3 patients discussed demonstrated a lack of cross-reactivity between moxifloxacin and ciprofloxacin since they tolerated oral challenge tests and full treatment courses of ciprofloxacin. Moxifloxacin has unique side chains at positions 7 and 8 on its bicyclic ring structure. Antigenic specificity to particular side chains at positions 7 and Similarly, 3 of buy female viagra 4 levofloxacin-reactive patients tolerated ciprofloxacin. Patients who reacted to moxifloxacin and norfloxacin tolerated ciprofloxacin and levofloxacin. CONCLUSIONS- Results suggest that skin testing and BAT do not help to identify the culprit drug or predict cross-reactivity. Oral challenge testing is the only way to confirm Controversy exists regarding the cross-reactivity risk for quinolone allergic reactions. Herein, we present a patient experiencing moxifloxacin anaphylaxis who could tolerate another class of quinolone Methods: Prick skin testing (PST) and oral graded challangePatients who reacted to moxifloxacin and norfloxacin tolerated ciprofloxacin and levofloxacin. Our results suggest that skin testing and BAT do not help to identify the culprit drug or predict With the recent introduction of agents such as gatifloxacin and moxifloxacin, the traditional gram-negative coverage of fluoroquinolones has been expanded to include specific gram-positive organisms.