In one placebo-controlled trial (n = 40), combat veterans with intractable trauma nightmares and other sleep disturbances were randomized to placebo or an initial prazosin dose of 1 mg PO at bedtime. The prazosin dose could be gradually titrated up to a maximum daily dose of 15 mg/day (5 mg in the morning and 10 mg at bedtime) if clinically indicated.A systematic review of the literature supports the use of prazosin for treating nightmares related to posttraumatic stress disorder (PTSD). The drug is well tolerated and can be titrated to effect.effects prohibited use, or a maximum daily dose of 20 mg was achieved. If 10 mg was required, the additional prazosin dose was given as a separate dose in the early evening. A total of 51 patients began treat-ment. Patients who did not have the prazosin prescription filled were designated the treatment com-Drug was titrated based on nightmare response over 6 weeks to a possible maximum dose of 5 mg midmorning and 20 mg at bedtime for men and 2 mg midmorning and 10 mg at bedtime for women. Mean achieved bedtime doses were 15.6 mg of prazosin (SD=6.0) and 18.8 mg of placebo (SD=3.3) for men and 7.0 mg of prazosin (SD=3.5) and 10.0 mg of placebo (SD Mar 16, 2018Half of the participants received prazosin and the others received placebo for 26 weeks. Women in the study assigned to prazosin received a maximum dose of up to 2 mg at midmorning and 10 mg at bedtime; men received a maximum of 5 mg of prazosin at midmorning and 15 mg at bedtime.zosin maximum dose is 20 mg daily. In another study, ‘Efficacy of Adjunct Sleep Interventions for PTSD’, the maximum dose of prazosin is 15 mg daily. In ‘Prazosin for Noncombat Trauma PTSD’, the maximum dose used is 25 mg daily. The high-est dose of prazosin used clinically is 50 mg daily High-dose prazosin for the treatment ofThe drug prazosin, used widely to help ease PTSD nightmares, did no better than viagra phone orders placebo in a large VA trial. Despite the apparent overall failure, the researchers contend there may be subgroups of Veterans who do in fact benefit from the treatment. Mar 22, 2012The maximum mean dose of prazosin was 2.3 0.7 mg (range, 2–4 mg) daily. After 8 weeks of treatment, 8 of the patients had greater than 50% reduction in nightmares (P .001). CGI-C scores indicated that 8 of the patients experienced moderate to …All of these studies support the efficacy of prazosin either for treating nightmares and improving sleep or for reducing the severity of PTSD. Treatment of PTSD with prazosin is usually initiated at a dose of 1 mg, with monitoring for hypotension after the first dose. The dose is then gradually increased to maintenance levels of 2–6 mg at night.A total of 187 male participants (54% in the prazosin group vs. 70% in the placebo group, P=0.003) reached the maximum dose of 20 mg; the mean maintenance http://canadabuyes.com female viagra does it work dose reached for both men and women was 14.86.1 mg in the prazosin group as compared with 16.45.9 mg in the placebo group (P=0.009).Become a Member May 30, 2017All the case reports showed a marked improv ement in nightmares when prazosin was prescribed to children, although typically it was prescribed at lower doses than in adults, between 1 …Prazosin side effects. Prazosin oral capsule may cause dizziness and drowsiness after your first dose. Avoid driving or performing any hazardous tasks for the first 24 hours after taking this medication or when your dose is increased. This drug can also cause other side effects.